Studentificaton refers to the process of social, environmental and economic change effected by large numbers of students invading particular areas of the cities and towns in which popular universities are located. In North America, a college town or university town is a community (often literally a town, but possibly a small or medium sized city, or in some cases a neighborhood or a district of a city) which is dominated by its university population. The university may be large, or there may be several smaller institutions such as liberal arts colleges clustered, or the residential population may be small, but college towns in all cases are so dubbed because the educational institution(s) presence pervades economic and social life. Many local residents may be employed by the university, many businesses cater primarily to the university, and indeed the students population may outnumber the local population outright.

In Europe, a university town is generally characterized by having an old university often founded before, or in some cases shortly after, the industrial revolution. The economy of the city is closely related with the university activity and highly supported by the entire university structure which may include university hospitals and clinics, university printing houses, libraries, laboratories, business incubators, student rooms, dining halls, students' unions, student societies, and academic festivities. Moreover, the history of the city is often indissociable from the history of the university itself. Many European university towns have not been merely important places of scientific and educational endeavor, but also centers of political, cultural and social influence to its respective society throughout the centuries. Examples of these cities include, Durham, St Andrews, Leiden, Bologna, Salamanca, Coimbra, Leuven, Heidelberg, Göttingen, Pisa, Marburg, Ferrara, Uppsala, Siena, Pavia, Delft, Tübingen, or Poitiers.

Besides a highly educated and largely transient population, a stereotypical college town often features a high number of people living non-traditional lifestyles and subcultures ("college town hippies") and high tolerance for unconventionality in general, an unusually active musical or cultural scene, and unusually left-wing politics. While relatively absent of heavy industry, many have become centers of technological research and innovative startups.